In the general population, both sexual dysfunction and depression are prevalent. It is possible for them to negatively affect one another in both directions when they coexist. Although no medication can be totally blamed for causing sexual dysfunction, serotonergic drugs like selective serotonin reuptake inhibitors (SSRIs), serotonin and noradrenaline reuptake inhibitors (SNRIs) and are mostly often linked to antidepressant-induced sexual dysfunction. Long-term treatment compliance could be jeopardized, which could have negative effects. Different psychological and pharmaceutical techniques, such as the sporadic use of sildenafil, may provide some relief.